Phage Encoded H-NS: A Potential Achilles Heel in the Bacterial Defence System
Identifieur interne : 000668 ( Main/Exploration ); précédent : 000667; suivant : 000669Phage Encoded H-NS: A Potential Achilles Heel in the Bacterial Defence System
Auteurs : Connor T. Skennerton [Australie] ; Florent E. Angly [Australie] ; Mya Breitbart [États-Unis] ; Lauren Bragg [Australie] ; Shaomei He [États-Unis] ; Katherine D. Mcmahon [États-Unis] ; Philip Hugenholtz [Australie] ; Gene W. Tyson [Australie]Source :
- PLoS ONE [ 1932-6203 ] ; 2011.
Abstract
The relationship between phage and their microbial hosts is difficult to elucidate in complex natural ecosystems. Engineered systems performing enhanced biological phosphorus removal (EBPR), offer stable, lower complexity communities for studying phage-host interactions. Here, metagenomic data from an EBPR reactor dominated by
Url:
DOI: 10.1371/journal.pone.0020095
PubMed: 21625595
PubMed Central: 3097231
Affiliations:
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Mcmahon</name><affiliation wicri:level="2"><nlm:aff id="aff7"><addr-line>Department of Civil and Environmental Engineering, University of Wisconsin at Madison, Madison, Wisconsin, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Civil and Environmental Engineering, University of Wisconsin at Madison, Madison, Wisconsin</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Hugenholtz, Philip" sort="Hugenholtz, Philip" uniqKey="Hugenholtz P" first="Philip" last="Hugenholtz">Philip Hugenholtz</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Australian Centre for Ecogenomics, School of Chemistry and Molecular Biosciences and Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Centre for Ecogenomics, School of Chemistry and Molecular Biosciences and Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Tyson, Gene W" sort="Tyson, Gene W" uniqKey="Tyson G" first="Gene W." last="Tyson">Gene W. Tyson</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Advanced Water Management Centre, The University of Queensland, St. Lucia, Queensland, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Advanced Water Management Centre, The University of Queensland, St. Lucia, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Australian Centre for Ecogenomics, School of Chemistry and Molecular Biosciences and Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Centre for Ecogenomics, School of Chemistry and Molecular Biosciences and Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The relationship between phage and their microbial hosts is difficult to elucidate in complex natural ecosystems. Engineered systems performing enhanced biological phosphorus removal (EBPR), offer stable, lower complexity communities for studying phage-host interactions. Here, metagenomic data from an EBPR reactor dominated by <italic>Candidatus</italic> Accumulibacter phosphatis (CAP), led to the recovery of three complete and six partial phage genomes. Heat-stable nucleoid structuring (H-NS) protein, a global transcriptional repressor in bacteria, was identified in one of the complete phage genomes (EPV1), and was most similar to a homolog in CAP. We infer that EPV1 is a CAP-specific phage and has the potential to repress up to 6% of host genes based on the presence of putative H-NS binding sites in the CAP genome. These genes include CRISPR associated proteins and a Type III restriction-modification system, which are key host defense mechanisms against phage infection. Further, EPV1 was the only member of the phage community found in an EBPR microbial metagenome collected seven months prior. We propose that EPV1 laterally acquired H-NS from CAP providing it with a means to reduce bacterial defenses, a selective advantage over other phage in the EBPR system. Phage encoded H-NS could constitute a previously unrecognized weapon in the phage-host arms race.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Canchaya, C" uniqKey="Canchaya C">C Canchaya</name></author><author><name sortKey="Fournous, G" uniqKey="Fournous G">G Fournous</name></author><author><name sortKey="Chibani Chennoufi, S" uniqKey="Chibani Chennoufi S">S Chibani-Chennoufi</name></author><author><name sortKey="Dillmann, M L" uniqKey="Dillmann M">M-L Dillmann</name></author><author><name sortKey="Brussow, H" uniqKey="Brussow H">H Brussow</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fuhrman, Ja" uniqKey="Fuhrman J">JA Fuhrman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brussow, H" uniqKey="Brussow H">H Brussow</name></author><author><name sortKey="Bruttin, A" uniqKey="Bruttin A">A Bruttin</name></author><author><name sortKey="Desiere, F" 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